The New Changed NP Thyroid

In September, the NP Thyroid pills changed in color, size, and shape.  The 60 mg pill changed from solid tan to gray with speckles.  The size and shape also changed slightly.  According to Acella, the company changed suppliers for the raw ingredient used in the medication.  The company states that the medication has the same formulation.

I respectfully disagree.  While the company may consider the "formulation" to be the same, the ingredients cannot be identical when the color and size of the pills have changed.  Many patients reported adverse effects as they began taking the new pills in August and September.

It was in late August that I became aware that the pills had changed.  I sorted my pills by old and new.  I took all of the old pills until I ran out of those.  I switched over to the new pills in late September.  By the middle of October, I was sick with hyperthyroid symptoms.  I suspect that the new pills temporarily resulted in a spike in thyroid hormone.  Having too much thyroid hormone in the blood is far worse than not having enough, in my experience.  I am very sensitive to the thyroid hormones. 

I also believe that my body is not absorbing the new pills as well as it did the old pills.  This matches other patients' reports.  The coating on the new pill is apparently harder than the coating on the old pill.  This would be the cause of the poor absorption.

While my thyroid hormone levels temporarily spiked in October, ultimately they decreased.  By early November, I felt okay again for around two weeks.  I believe that my levels were steadily dropping during that time, and for a brief period in early November, my levels were about right.  By November 15, I felt like my thyroid hormone levels were a little low.

Beginning Thursday, November 21, I felt a significant decrease in wellness each successful day up to Monday, November 25.  In addition to unpleasant hypothyroid symptoms, my blood pressure spiked by around 20 points.  I felt worse day by day, with the reappearance of more symptoms each day.  Fortunately, my three-month checkup was on November 25.

My thyroid hormone levels, both T3 and T4, had dropped due to the change in the NP Thyroid pill.  The T4 level had dropped a lot.

I do take another thyroid medication, Tirosint, in addition to NP Thyroid.  Tirosint is T4 only while NP Thyroid is a combination of T4 and T3.  My Tirosint dosage was doubled to make up for the T4 deficit caused by the change in the NP Thyroid pills.

Just a few hours after I took the new Tirosint dosage, my blood pressure dropped by 20 points and stayed down.  I felt warmer, although other symptoms will take longer to diminish.

Unfortunately, this means that I am at the beginning of yet another difficult medication adjustment period.  I probably will continue to feel better for around the next week.  After that, I will begin to feel sick.  This happens because the pituitary gland senses the sudden increase in T4 in the body due to the medication increase.  The pituitary gland then temporarily shuts down the thyroid, which then makes the patient feel sick for two to five weeks, or possibly even longer.

The lengthy adjustment period is caused by the long half-life of T4.  It takes weeks for the hormone to build up in the body.

I always go through a 2 to 2 1/2 month adjustment period before the levels completely sort out.

So if you take NP Thyroid and are no longer well, you are not imagining it.